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Cayman Chemical PAMAM Dendrimer G2.0 Amidoethanol (water solution), 500 mg
A hydroxyl-terminated PAMAM dendrimer; has been used as a drug delivery system in vitro; ~29.4 Å in diameter in water and has 16 surface groups; an antagonist of PA63 in lipid bilayers (IC50 = 142 nM); inhibits the proliferation of MCF-7 and MDA-MB-231 cells at 100 µM; enhances the water solubility of erythromycin and increases the antifungal activity of clotrimazole against Candida; fragmentation of PAMAM G2.0 amidoethanol with hydrogen peroxide produces a fluorescent unsaturated hydroxylamine, which selectively detects hypochlorite over several other ROS and has been used to detect intracellular hypochlorite levels in RAW 246.7 macrophages
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